{"id":8718,"date":"2022-10-31T12:33:35","date_gmt":"2022-10-31T11:33:35","guid":{"rendered":"https:\/\/science-nutrition.com\/?p=8718"},"modified":"2022-11-02T13:00:11","modified_gmt":"2022-11-02T12:00:11","slug":"lefsa-confirme-la-toxicite-des-derives-hydroxyanthraceniques-dans-les-aliments","status":"publish","type":"post","link":"https:\/\/science-nutrition.com\/en\/2022\/10\/31\/lefsa-confirme-la-toxicite-des-derives-hydroxyanthraceniques-dans-les-aliments\/","title":{"rendered":"EFSA confirms the toxicity of hydroxyanthracene derivatives in food"},"content":{"rendered":"
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In accordance with Article 31 of Regulation (EC) No 178\/2002, the European Commission asked EFSA to assess whether the data from two new scientific publications presented by the Italian society of toxicology were sufficient to revise their conclusions<\/span><\/span> on the safety of hydroxyanthracene derivatives in foods<\/a>.<\/span><\/span><\/span><\/em><\/p>\n

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These 2 new scientific publications concern two in vivo<\/em> comet tests in mice conducted respectively on Aloe\u2010emodin<\/strong> and the whole dried juice of Aloe ferox<\/em><\/strong>.<\/span><\/span><\/span><\/div>\n
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  1. The results of the study with aloe-emodin were considered inconclusive for the induction of DNA strand breaks with the standard comet assay protocol.<\/span><\/span> Results obtained with the modified comet assay protocol with a lesion-specific enzyme (hOGG1) suggest that aloe\u2010emodin can induce oxidative DNA damage in colon cells in vivo<\/em>.<\/span><\/span><\/span><\/li>\n
  2. The absence of DNA damage observed in the Aloe ferox<\/em> juice study was considered of little relevance with respect to the genotoxicity of hydroxyanthracene derivatives, due to the low concentrations of hydroxyanthracene derivatives and<\/span><\/span> the potential antagonistic effect of other components present in the juice (for example, antioxidants).<\/span><\/span><\/span><\/li>\n<\/ol>\n

    Thus, the two studies by Galli et al.<\/span><\/span> (2021 a<\/a> & b<\/a>) do not justify a revision of the conclusions of the EFSA ANS Panel on the safety of hydroxyanthracene derivatives for food use.<\/strong><\/span><\/span><\/span><\/p>\n

    To know more, you can consult:<\/p>\n