The European Commission requested the EFSA to update the framework for Tolerable Upper Intake Level (UL) assessment and the current ULs for some vitamins and minerals. When it was not possible to establish an UL, the Commission requested the ESA to determine the safe level which is an indication on the highest level of intake for which there is a reasonable confidence on the absence of adverse effects. Consequently, the EFSA published until 2024 the guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals and the scientific opinions on the tolerable upper intake for preformed vitamin A and bêta-carotene, for vitamin E, for vitamin D, and some essential minerals such as iron, manganese, selenium
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